The Global Fund Impact

The vision of the Global Fund is to achieve a world free of the burden of HIV, TB and malaria. The strategy is to invest for impact.





Accelerating the end of AIDS, tuberculosis and malaria as epidemics

The Global Fund partnership mobilizes and invests nearly US$4 billion a year to support programs run by local experts in countries and communities most in need. The impact of investments in health can be measured in many ways, including how many lives are saved, and the rate of decline in HIV, TB and malaria, and other methods. In a broad sense, the real impact of investments in health is the vitality and economic strength of communities and countries where the burden of disease is retreating.

Number of lives saved through Global Fund-supported programs

In 2000, AIDS, tuberculosis and malaria appeared to be unstoppable. The world fought back. As a partnership of governments, the private sector, civil society and people affected by the diseases, the Global Fund pooled the world’s resources to invest strategically in programs to end AIDS, TB and malaria as epidemics. It is working.

The Global Fund partnership supports programs that have saved more than 22 million lives as of 2016. We can’t stop now. We need to accelerate our efforts to build on this amazing progress and prevent a resurgence of the diseases. Our partnership has set performance targets for the Global Fund Strategy 2017-2022. Programs supported by the Global Fund will save 14 million lives in the three-year period beginning in 2017, bringing the total lives saved by the Global Fund partnership to 36 million by the end of 2019. Those programs will also avert up to 194 million new infections or cases of HIV, TB and malaria.

In the past 15 years, the Global Fund and our partners have achieved what was once considered impossible. The number of HIV-related deaths has been cut by nearly half, from 1.9 million people at the peak of the crisis to 1 million in 2016.

The rapid increase in access to ARV therapy in countries supported by the Global Fund – from 3 percent coverage in 2005 to 21 percent in 2010 and 52 percent in 2016 – has been a tremendous contributing factor. Through Global Fund-supported programs, more than 11 million people are receiving lifesaving ARV therapy – more than half the total number of people on treatment worldwide.

The number of HIV infections is falling. Between 2000 and 2016, the number of new HIV infections declined by 40 percent in countries supported by the Global Fund. Global Fund-supported programs have provided 4.2 million HIV-positive mothers with treatment to prevent transmission of HIV to their babies.

Overall, the story of progress against TB is commendable. Global TB treatment programs averted 49 million deaths between 2000 and 2015 (including 10 million HIV-positive people).

The number of deaths from TB in 2015 would have been more than three times higher in absence of interventions. In countries supported by the Global Fund, the mortality rate from TB declined 35 percent and actual deaths declined 21 percent between 2000 and 2015 (excluding HIV-positive people). Additionally, the number of TB cases in countries where the Global Fund invests went down 5 percent between 2005 and 2015.

TB hunters

The fight against malaria is the biggest success story of the 21st century. The number of deaths caused by malaria globally declined 50 percent between 2000 and 2015 – that translates to an estimated 6.8 million deaths averted. The number of malaria cases has declined rapidly, dropping by more than 18 percent in that same period, resulting in a total of 1.3 billion malaria cases averted globally between 2001 and 2015.

The simplest and most effective malaria preventive tool is a long-lasting insecticidal net that a family can hang over their sleeping area. More than 795 million mosquito nets have been distributed through Global Fund-supported programs.

Cases of malaria treated through Global Fund-supported programs rose 15 percent in the past year alone, to hit a cumulative total of 668 million by end 2016.

People currently on antiretroviral therapy through Global Fund-supported programs

There are 19.5 million people around the world on treatment for HIV, 11 million of them through programs supported by the Global Fund as of 2016. Today, with access to lifesaving treatment, an HIV-positive person can expect to have the same lifespan as someone who is HIV-negative.

One of the cornerstones of this lifesaving treatment is the use of antiretrovirals (ARVs). ARVs are given as a combination of drugs that can reduce the amount of HIV in the body or prevent HIV in people at substantial risk of acquiring the virus. However, ARVs are not a cure for HIV; a person living with HIV who is on treatment will need to take ARVs the rest of their life. ARVs also have another benefit: treatment reduces the chance that an HIV-positive person will pass the virus on to someone else by 97 percent.

There are four ways HIV can be spread from one person to another:

  • Through infected blood or blood products

  • Through contaminated needles, syringes, or other injecting equipment

  • Through exchange of bodily fluids, such as during sexual intercourse

  • Through pregnancy, childbirth or breastfeeding.

Tuberculosis is one of the world’s most deadly infectious diseases. In 2016, TB killed 1.7 million people, including 374,000 people with HIV, making it the ninth leading cause of death worldwide.

TB is spread from person to person through coughing and sneezing. One person with active, untreated TB can spread the disease to as many as 15 other people in a year. This makes the hunt for “missing cases” – those currently not diagnosed, treated or reported – all the more urgent. With an estimated 10.4 million new cases of TB every year, we must accelerate progress.

Making TB screening routine can help reduce the stigma associated with the disease.

A mosquito bite can kill. It’s as simple as that. Malaria is caused by parasites transmitted through the bite of an infected female Anopheles mosquito, causing nearly 429,000 deaths a year. Children and pregnant women are particularly vulnerable – in 2015, almost 70 percent of all malaria deaths were children under 5.

Once prevalent across most of the globe – including much of the American South and Northern Italy – elimination efforts of the 20th century have reduced malaria’s footprint to 91 countries. Today, however, half of the world’s population – 3.2 billion people – remains at risk of malaria.

Boots on the ground against malaria